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8 Additionally, broad-spectrum antibiotics do not reduce hospitalization duration, 30- or 90-day readmission rates, time to the next exacerbation, or mortality in non-ICU COPD patients
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The liver is a key target organ for methylation reactions where SAM is the methyl donor (Figure 1(a)) and participates in posttranslational protein modifications, DNA and histone tail methylation, as well as many metabolic pathways such as creatine synthesis [13–15], carnitine synthesis [16, 17], and endogenous phosphocholine synthesis [18]
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